Weekend Wonderings

Written April 19th, 2014 by Ken

th_chimpWelcome to this week’s edition of Weekend Wonderings. I hope that you have a nice, enjoyable Easter weekend and get ample “family” time. So, if you’re reading this on Sunday, I appreciate it, but get back to your family. You can catch this later Sunday or Monday.. Oh, and if you’re visiting, safe travels to you. Regardless, grab whatever beverage that you need and let’s proceed.

The James/Wexner

Study Identifies a Likely Key Driver of Colorectal Cancer Development and Progression

  • New targets are needed for agents that will more effectively treat colorectal cancer.
  • This study identifies a molecule that is probably a key driver of colorectal cancer.
  • The findings strongly suggest that this molecule could be an important therapeutic target and a valuable biomarker of colorectal cancer tumor progression.

A new study identifies a molecule that is a probable driving force in colorectal cancer and suggests that the molecule could be an important target for colorectal cancer treatment and a valuable biomarker of tumor progression.

“We found that miR-135b is up-regulated in both sporadic and inflammatory bowel disease-associated colorectal cancer, and that its up-regulation is associated with tumor stage and poor clinical outcome,” says principal investigator Carlo M. Croce, MD, chair of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics at Ohio State and the OSUCCC – James.

Some more progress in James-led research. We’ve got to keep ahead of this stuff..

New Emergency Department at The James

The new James/Wexner will have an Emergency Department geared towards  the special conditions experienced by cancer patients.


C’mon kid, use your head:

A news tidbit making the rounds this week (slow news week) is the dismissal of quarterback Chad Kelly from the Clemson roster, triggered by a sideline spat with his coaches during their Spring Game last Saturday. It made the news in western New York because Chad is the nephew of former Bills quarterback and demigod, Jim Kelly. An article appeared in The Buffalo News, by Jerry Sullivan, with some background and opinion. I’m mentioning this in today’s article because I’m sure there is a “moral to the story” somewhere, plus back in one of my Corporate Jobs, Chad’s mother worked for me.. Degrees of separation, man. To get the full flavor of this, I suggest that you take a few minutes to read the two above articles.

Evidently, from Shakin’ The Southland:

Chad Kelly’s Clemson football career has come to a close.  Kelly, the fiery 2012 enrollee, capped off a tough weekend by getting dismissed from the Clemson football program by Dabo Swinney.  Yesterday we discussed Kelly’s poor Spring Game outing and his ridiculous insubordinate sideline outburst following a coaching decision to punt on 4th and 3 around mid-field.  Chad Morris and Jeff Scott recommended Kelly be benched for the balance of the game and Swinney concurred, causing Kelly to show out even more on the sidelines.

Evidently, in the first half of the Spring Game, at one point the offense faced a 4th-and 3 from midfield and Coach Dabo Swinney decided to punt. Kelly took exception to it, and the rest is history. At least as far as the Clemson and Kelly relationship goes. But wait, there’s more:

 “He has had a pattern of behavior that is not consistent with the values of our program,” Swinney said.

That’s the disconcerting part; evidently the Saturday outburst was the ‘straw > camel’s back’ episode. Why on earth would you get exercised about a coach’s decision in a Spring Game of all things? Could it have been hubris and immaturity on the player’s part? Most likely. His actions ended his collegiate career at Clemson, raises behavior flags for himself and puts the Clemson program in a bit of a bind at the QB position that they didn’t need. It’s one thing to be uber-competitive, and as you’ve read in the articles, it’s quite another to be self destructive with it. But then when your nickname is “Swag”.. yeesh.

The Kelly family has more serious issues at hand, since Jim’s mouth cancer  has recently re-emerged. Here’s hoping that Jim has successful treatment and soon gets back to a normal life, and hoping that his nephew grows up.

Trailing Off: 

About 25 years ago I took a position with a consulting firm and Lovely Bride and I had to move out of state. When we applied for a mortgage for our new home, I was listed/considered “head of household” on the loan application form. On the same application forms, my wife was listed as “trailing spouse”.  Obviously, this didn’t sit too well. When, somewhat indignantly asked what was meant by “trailing spouse”,  the banker explained to the effect that “Since your husband took the job in (insert city) and you moved down here to be with him, you trailed here after him”.

While technically true, perhaps just the term “spouse” would have been a better choice. I’m assuming the banking community has reworded some of their forms. However, since the phrase is a good bit funnier now than it was 25 years ago, it still comes up now and then.. in a light-hearted context, of course..

Sunday’s Song

Not necessarily pointed at the Kelly’s (but read into int what you want..) but for our upcoming tBBC “new fathers”, here are Tula and Roberto from ‘Playing For Change’ cover Crosby, Stills & Nash’s Teach Your Children.



  1. CharlesNo Gravatar
    April 23rd, 2014 at 2:35 am

    Thanks for including the thing about the new cancer patient emergency department. I had never really thought about the need for a separate ED for cancer patients before but after reading the linked article, I see that it makes a lot of sense.


    KenNo Gravatar
    April 24th, 2014 at 8:35 am

    Thanks, Charles. I never really gave it any thought either, but when you see the unique issues of cancer patients, it does make sense. These folks at The James seem to think of everything..


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