Weekend Wonderings

Written April 27th, 2014 by Ken

chimp_skullWelcome to this week’s edition of Weekend Wonderings. Despite a dash of snow here and there the past week or so, it appears as if Spring is here and Summer will be wandering in, in due time.

The James/Wexner 

Gene within a gene:  A small gene that is embedded in a larger, well-known gene is the true leukemia-promoting force usually attributed to the larger gene, according to a new study by researchers at The OSUCCC – James. Here’s the abstract;

  • High expression of a gene called BAALC is known to be associated with poor survival in acute myeloid leukemia (AML) patients.
  • BAALC has a second smaller gene embedded within it that is also active in AML.
  • This study shows that, of the two, the smaller gene is the major driver of AML development, and it identifies a drug that might inhibit the smaller gene’s activity.

Here’s a link to the article.

This study again confirms that there really isn’t a necessarily a “cancer gene”. Very often, the combined effect that one or more genes have on each other, epistasis, will cause genes to express themselves.

Viewing Pleasure: Here is an entertaining, informative (and short) video that walks us through the Clinical Trials Unit at the new James Hospital. We are led on this tour by Dr. Richard Goldberg.


A bit of an olio today, folks.

Southern Hospitality: It seems like the state guv’mint of Georgia has done done it this week. By passing HB-60 (The Safe Carry Protection Act of 2014) the have specified (and widened)

“..where Georgia residents can carry weapons. Included are provisions that allow residents who have concealed carry permits to take guns into some bars, churches, school zones, government buildings and certain parts of airports.”

Airports!? I’m sure the TSA is thrilled about that. Churches? Note to pastors, be careful about your sermonizing. HB-60 did provide an out of sorts by allowing certain property owners, specifically churches and bars, to prohibit gun carrying by worshipers and customers. However, hypocrisy sense did prevail in that guns are not permitted in the State Capitol building, and other government buildings. No sense the fine Representatives of GA taking the risk of an upset (and armed) constituent paying a visit.

And, if we’re going to get 2nd Amendment’y here:

A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed.

I doubt that the gun-toters, a) belong to the National Guard, which would pass for a militia today, and b) certainly wouldn’t want to be “well regulated”.

Better Than Cliff Notes:

This article in Bloomberg View is fairly entertaining.  Megan McArdle writes a column where she reviews a book that she admits she hadn’t yet read. Seriously. Her comments and opinions are based, evidently, on reading  the reviews of others and her own leanings.

I only wish that my college professors were as understanding and obliging to me as her Editors are to her.

Sunday’s Song

In remembrance of Rubin “Hurricane Carter’s” passing last Sunday, Hurricane.


  1. WVaBuckeyeNo Gravatar
    April 28th, 2014 at 8:38 am

    Ken, great stuff my friend. The amazing thing about genetics studies around diseases and all of them trying to find cures through such began with Cystic Fibrosis in 1988 with the discovery of the gene that causes CF. Great progress in over 25 years of research. One day they will conquer diseases. I pray


    KenNo Gravatar
    April 28th, 2014 at 12:47 pm

    WVa, excellent point, thanks for bringing that up. Those diseases “CF” and “C” are truly horrific diseases. I think that cancer, and other disease researchers owe a debt of gratitude to the CF researchers to illustrate what can be done concerning cause, and hopefully cure and prevention of these types of diseases.


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