Weekend Wonderings

Written April 19th, 2014 by Ken

th_chimpWelcome to this week’s edition of Weekend Wonderings. I hope that you have a nice, enjoyable Easter weekend and get ample “family” time. So, if you’re reading this on Sunday, I appreciate it, but get back to your family. You can catch this later Sunday or Monday.. Oh, and if you’re visiting, safe travels to you. Regardless, grab whatever beverage that you need and let’s proceed.

The James/Wexner

Study Identifies a Likely Key Driver of Colorectal Cancer Development and Progression

  • New targets are needed for agents that will more effectively treat colorectal cancer.
  • This study identifies a molecule that is probably a key driver of colorectal cancer.
  • The findings strongly suggest that this molecule could be an important therapeutic target and a valuable biomarker of colorectal cancer tumor progression.

A new study identifies a molecule that is a probable driving force in colorectal cancer and suggests that the molecule could be an important target for colorectal cancer treatment and a valuable biomarker of tumor progression.

“We found that miR-135b is up-regulated in both sporadic and inflammatory bowel disease-associated colorectal cancer, and that its up-regulation is associated with tumor stage and poor clinical outcome,” says principal investigator Carlo M. Croce, MD, chair of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics at Ohio State and the OSUCCC – James.

Some more progress in James-led research. We’ve got to keep ahead of this stuff..

New Emergency Department at The James

The new James/Wexner will have an Emergency Department geared towards  the special conditions experienced by cancer patients.

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OSU Athletic Band Review: Spring Football Game

Written April 18th, 2014 by Charles

athletic_band_logo

Fans who attended the Ohio State spring football game last weekend were probably not surprised to see a band in attendance, after all, what OSU football game would be complete without a band to play Fight The Team and Hang On Sloopy? However as the game went on, there were many fans who were probably surprised and confused by some of the things that the saw from the band. Was the band wearing red polo shirt and black baseball hats, what happened did TBDBITL get new uniforms? And where was the traditional ramp entrance and what about Script Ohio? Wait, are those woodwinds in the band? The explanation for these questions is tied to the fact that the band at the spring football game wasn’t the Ohio State Marching Band which Buckeye fans are used to seeing in Ohio Stadium in the fall. Rather, it was the Ohio State Athletic Band, the other band on campus that performs at OSU sporting events over the course of the year.

Unlike the marching band which is all brass and percussion and limited to 225 members who must tryout, the athletic band also includes woodwinds and is a non-audition group; in recent years the band that performs at men’s basketball games has required an audition. The lack of audition does not mean that quality is not important to the athletic band; members are very talented and are expected to perform at high levels. The band rehearses twice a week for two hours at a time each semester as well as performing at games most every weekend, leading to a very busy schedule.

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Silver Bullet Points Salutes You

Written April 16th, 2014 by MaliBuckeye

Those of you who play along with us during Fall liveblogs know my propensity for helping make stadium sound effects on third down as a way to manage my ADD help the team. As such, today’s news hit me with a bit of both nostalgia and sadness… The band that gave us the bell may be no more. We’ve only got one choice for today’s soundtrack, then… Happy Wednesday!

For Those About To Rock…. Fire!

Buckeye 411

WNR Special Edition: CBJ in the NHL Playoffs, round 1

Written April 15th, 2014 by Jason

For the first time since 2008, and only the second time in franchise history, the Columbus Blue Jackets have qualified for the Stanley Cup Playoffs. The postseason birth was clinched last Wednesday as a result of a 4-3 win over the Dallas Stars. Saturday nights season ending win over the Florida Panthers cinched up the 7 seed and top wild card spot. The Jackets now travel to Pittsburgh to take on the Penguins for game 1 of the 7 game series starting tomorrow night at 7:30. WebRenew_Playoffs_400x255

If there were ever a time to get on the CBJ bandwagon it is now. And if you’re on the fence and you’re a Cleveland and Cincinnati sports fan, well I have two words for you: Playoffs and Pittsburgh. If that doesn’t get the adrenaline flowing you may not have a pulse. I want to beat Pittsburgh in everything from football to hockey to marbles.

The Jackets come into the series on a wave of momentum going 4-1 over a five game stretch in a mere 7 days. That’s like the Bengals or the Browns playing on Monday night, two nights later on Thursday night and then again on Sunday and winning 2 of the 3.

I’ve professed my new-found love for hockey by making sure to preface it with the fact that I still don’t really understand what I’m watching. Though the picture is getting a little clearer, for example it’s becoming easier to pick up on sets they are running and seeing plays develop, it’s still all so new. Read More

Non Revenue: Men’s Golf Update

Written April 15th, 2014 by Ken
osumensgolf1

The Ohio State University Men’s Golf Team

Spring has finally arrived, mostly, The Masters tournament field succumbed to Bubba-Golf and I (finally) got my first round of the year in the books. So, let’s talk golf. Specifically, Ohio State University golf.

That was Then…

The Buckeyes have had their moments on the NCAA courses, enough for me to say there is a good golf tradition at Ohio State. Although the University only has two NCAA Championship teams it can point to (1945, 1979) there are several notable players that came through Columbus. Off the top of my head, the two most notable were Jack Nicklaus (turned pro in ’61) followed closely by Tom Weiskopf (turned pro in ’64). The other two that come to mind are John Cook (turned pro in ’79) and the pride of Horseheads NY, Joey Sindelar (turned pro in ’81).

While at Ohio State, Nicklaus won three top amateur tournaments, was NCAA champion and came in 2nd in the U.S. Open (won by Arnold Palmer).   Weiskopf also won a top amateur event. Cook won five top amateur events, and Sindelar won only one event. However, Sindelar was a three-time All-American at Ohio State and in 1981 was voted the OSU Athlete of the Year.

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Weekend Wonderings

Written April 13th, 2014 by Ken
boyd4

Boyd Crowder still decidin’ whether to itemize or take the standard deduction.

Welcome to this week’s edition of Weekend Wonderings. Basketball season is finally over. Congratulations to the UConn Huskies for winning the men’s and the women’s NCAA Championships. Let the good times roll in Storrs, CT.  The OSU football team’s Spring game was yesterday, but I’m sure that I’ll have some thoughts in next week’s edition.

The James/Wexner

Well-Known Cancer Gene NRAS Produces Five Variants, Study Finds

  • NRAS is one of the most studied of cancer-related genes.
  • This study found that the gene produces five variants, not just one form as previously thought.
  • The finding might help improve drugs for cancers that involve NRAS.

A new study shows that a gene discovered 30 years ago and now known to play a fundamental role in cancer development produces five different gene variants (called isoforms), rather than just the one original form, as thought.

The study of the NRAS gene by researchers at the (OSUCCC – James) identified four previously unknown variants that the NRAS gene produces. The finding might help improve drugs for cancers in which aberrant activation of NRAS plays a crucial role. It also suggests that NRAS might affect additional target molecules in cells, the researchers say.

The isoforms show striking differences in size, abundance and effects. For example, the historically known protein (isoform 1) is 189 amino-acids long, while one of the newly discovered variants, isoform 5, is only 20 amino-acids long. Isoform 5 was the most aggressive variant in proliferation and transformation assays.

The last sentence and a half are not surprising. A smaller, “stripped-down” gene is much more likely to reproduce more quickly than its “bigger” brethren. As such, the isoform 5 variant may be the most dangerous of the five that were identified. As long as I’m on genes..

Here’s an article by Rameek Roychowdhury MD, PhD that explains genomics and its use at The James. It is a good, short overview, and a very good read.

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Silver Bullet Points Knows Who’s Boss

Written April 9th, 2014 by MaliBuckeye

Bruce came to visit Ohio last night… and at least one person had a great time at the eventUPDATE: Video Evidence. So, today’s soundtrack is one of my favorite songs from The Boss… even if it’s somewhat new, it’s still a classic.

 

Ohio State Quarter Back

Buckeye 411

  • Representing In North Texas- Aaron Craft was involved in this weekend’s festivities, although not in the way that any of us would hope. Not only did he get his one shining moment, but he was honored as the National Defensive Player of the Year as a part of the Final Four events.  He was also a part of work that the honorees did with Special Olympics basketball players, who undoubtedly left the opportunity more scrappy and tenacious for their efforts.
  • Taking One For The Team- Great article in Tuesday’s Dispatch about Joel Hale, a starter at nose guard last season and his decision to request a move to the offensive side of the ball for his senior season.
  • Good Gig If You Can Get It- Ohio State will be paying Virginia Tech, Cincinnati, and Kent State to bring their talents to the ‘Shoe for 2014.  This isn’t really all that unusual, but the $2 million total is pretty significant. It should be noted, though, that the Hokies will more than likely return the favor next season when the Buckeyes travel to Blacksburg.  The Buckeyes will see $850k return to their coffers when they face Navy to open the season, given that it’s a “neutral site” game in Baltimore.
  • Congrats, We Think- Dan Sanzenbacher has been re-signed as a professional athlete!  But it’s with the Bengals… so it’s hard to know whether or not to send flowers of celebration or condolences.
  • Gear- While there are a lot of reasons to be concerned about the welfare and circumstances of “student athletes”, “lack of awesome apparel” should not be one of them, as the latest offering from Sammy Silverman shows: Read More

Weekend Wonderings

Written April 6th, 2014 by Ken
Bruno

G Bruno

Welcome to this week’s edition of Weekend Wonderings. Basketball season is over, if you’re an Ohio State fan. And probably if you’ve gotten into any NCAA pools, as well. The Spring sports are well under way, and we have some time before OSU’s Spring Game. Grab whatever beverage that you need and let’s proceed.

The James/Wexner

An Overview of the BR-002 Trial in Breast Cancer:

Julia White, MD, professor, director, Breast Radiation Oncology, vice chair, Clinical Research, The Ohio State University Comprehensive Cancer Center, discusses the BR-002 trial, which will evaluate the rate of complete tumor ablation of breast cancers that are less than or equal to 2 centimeters.

Ablation refers to local methods that destroy the tumor without removing it. Ablation treatment of tumors does work. They do a tremendous job of it at The James.

Keeping up:

If you want to keep current with cancer research and treatment at The James, you can sign up to their blog.

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