Weekend Wonderings

Written June 22nd, 2014 by Ken


Welcome to this week’s edition of Weekend Wonderings. We have tidbits regarding The James, a couple miscellaneous commentary topics and a musical finale. Fire up the speakers, cause it’s Sunday morning!

Grab your beverage and let’s proceed.

 The James/Wexner:

Here is some research from the folks at The James regarding the use of a deadly life form, a virus, along with a cancer targeting agent to kill cancer cells. This is a creation of a hunter-killer approach to cancer treatment and therapy.

Giving low doses of a particular targeted agent with a cancer-killing virus might improve the effectiveness of the virus as a treatment for cancer, according to a study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James).

  • Viruses designed to kill cancer cells are being used in clinical trials to treat brain cancer and other malignancies.

  • This study suggests that combining a particular targeted agent with a cancer-killing virus might improve the virus’s ability to kill cancer cells.

  • The findings support the testing of this combination therapy in a clinical trial.

In other news, Dr. Carbone of The James discusses specific biomarkers to assist in diagnosis and treatment of lung cancer. It’s a long, long journey, but, small steps, folks..


Talkin’ Football: Musician Jon Bon Jovi’s name has been bandied about as a potential buyer for the Buffalo Bills.

That’s fine with me — someone has to own them. Read More

Weekend Wonderings

Written January 26th, 2014 by Ken

teacherWelcome to this week’s edition of Weekend Wonderings. The basketball teams are swimming upstream right now, and the current is strong. We see the destination, we need to just keep stroking.  Grab whatever beverage that you need and let’s proceed.

The James/Wexner, Cleveland Clinic

This is “virus” week on Weekend Wonderings. Let’s start with a brief refresher. From Berkeley Wellness article on August 2012:

“One in every six cases of cancer worldwide can be attributed to viruses and other infectious agents, a new study from the International Agency for Research on Cancer has confirmed.”

Which leads us to findings that the HPV virus can damage genes:

“Our sequencing data showed in vivid detail that HPV can damage host-cell genes and chromosomes at sites of viral insertion,” says co-senior author David Symer, MD, PhD, assistant professor of molecular virology, immunology and medical genetics at the OSUCCC – James.

“HPV can act like a tornado hitting the genome, disrupting and rearranging nearby host-cell genes,” Symer explains. “This can lead to overexpression of cancer-causing genes in some cases, or it can disrupt protective tumor-suppressor genes in others. Both kinds of damage likely promote the development of cancer.”

Read More

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